top of page


“The joy of discovery is certainly the liveliest that the mind of man can ever feel”

- Claude Bernard -

Please click on the titles for a link to the article.
If you'd like a copy of a publication, please get in touch. I am happy to provide PDFs



52. Cootes, TA., Bhattacharyya, ND., Huang, S., Daniel, L., Bell-Anderson, K., Stifter, SA., Chew, T., Solon-Biet, SM., Saraiva, LR., Cai, Y., Chen, X., Simpson, SJ., Feng, CG. (2022) The quality of energy- and macronutrient-balanced diets regulates host susceptibility to influenza in mice. Cell Reports, Accepted 30 Sep 2022.

51. Rodriguez Paris, V., Wont, XY., Solon-Biet, SM., Edwards, MC., Aflatounian, A., Gilchrist, R. Simpson, SJ., Handelsman, DJ., Kaakoush, NO., Walters, K. (2022) The interplay between PCOS pathology and diet on gut microbiota in a mouse model. Gut Microbes, 14:1. DOI: 10.1080/19490976.2022.2085961.

50. Raubenheimer, D., Senior, AM., Mirth, C., Cui, Z., Hou, R., Le Couteur, DG., Solon-Biet, SM., Leopold, P., Simpson, SJ. (2022) Dietary balance across the life course: an integrative approach. iScience, 25:104315. DOI: 10.1016/j.isci.2022.104315.

49. Le Couteur, DG., Raubenheimer, DR., Solon-Biet, SM., deCabo, R., Simpson, SJ. (2022) Does diet influence aging? Evidence from animal studies. J Int Med, DOI: 10.111/joim.13530.

48. Solon-Biet, SM., Griffiths, L., Fosh, S., Le Couteur, DG., Simpson, SJ., Senior, AM. (2022). Meta-analysis links dietary branched-chain amino acids to metabolic health in rodents. BMC Biology, 20:1. DOI 10.1186/s12915-021-01201-2.



47. Fotheringham, A., Solon-Biet, SM., Bielefeldt-Ohmann, H., McCarthy, D., McMahon, A., Ruohonen, K., Li, I., Sullivan, M., Whiddett, R., Borg, D., Cogger, V., Ballard, JWO., Turner, N., Melvin, R., Raubenheimer, D., Le Couteur., D., Simpson, SJ., Forbes, J. (2021). The impacts of chronic consumption of low dietary protein on kidney function and structure are not explained by traditional kidney disease risk factors. iScience, 24:11. DOI: 10.1016/j.isci.2021.103308.

46. Le Couteur, D., Solon-Biet, SM., Parker, BL., Pulpitel, T., Brandon, A., Hunt, N., Wali, J., Gokarn, R., Senior, A., Cooney, G., Raubenheimer, D., Cogger, V., James, DE., Simpson, SJ. (2021). Long-term nutritional regulation of liver proteome targets the spliceosome and mitochondria in mice. Cell Metabolism. DOI: 10.1016/j.cmet.2021.10.016.

45. Wali, J., Milner, A., Luk, A., Pulpitel, T., Dodgson, T., Facey, H. Wahl, D., Kebede, M., Senior, A., Brandon, A., Yau, B., Lockwood., G., Koay, Y., Ribeiro, R., Solon-Biet, SM., Bell-Anderson, K., O’Sullivan, J., Macia, L., Forbes, J., Gooney, G., Cogger, V., Holmes, A., Raubenheiner, D., Le Couteur, D., Simpson, S. (2021). Impact of dietary carbohydrate type and protein – carbohydrate interaction on metabolic health. Nature Metabolism. DOI: 10.1038/s42255-021-00393-9.


44. Wali, J., Solon-Biet, S.M., Freire, T., Brandon, A.E. (2021) Macronutrient determinants of obesity, insulin resistance and metabolic health. Biology, 10:336. DOI 10.3390/biology10040336.


43. Xu, X., Solon-Biet, S.M., Senior, A., Raubenheimer, D., Simpson, S.J., Fontana, L., Mueller, S. Yang, J.Y.H. (2020) LC-N2G: a local consistency approach for nutrigenomics data analysis. BMC Bioinformatics, 21:530. DOI: 10.1186/s12859-020-03861-3.


42. Le Couteur, D.G., Solon-Biet, S.M., Cogger, V.C., Ribeiro, R., de Cabo, R., Raubenheimer, D., Cooney, G.J., Simpson, S.J. (2020). Branched chain amino acids, aging and age-related health. Ageing Research Reviews, 64:101198. DOI: 10.1016/j.arr.2020.101198.


41. Rodriguez Paris, V., Solon-Biet, S.M., Senior, A.M., Edwards, M.C., Desai, R., Tedla, N., Cox, M.J., Ledger, W.L., Gilchrist, R.B., Simpson, S.J., Handelsman, D.J., Walters, K.A. (2020). Defining the impact of dietary macronutrient balance on PCOS traits. Nature Communications, 11:5262. DOI: 10.1038/s41467-020-19003-5.

40. Yap, Y.Y., Rusu, P.M., Chan, A.Y., Fam, B.C., Jungmann, A., Solon-Biet, S.M., Barlow, C.K., Creek, D.J., Huang, C., Schittenhelm, R.B., Morgan, B., Schmoll, D., Kiens, B., Piper, M.D.W., Heikenwalder, M., Simpson, S.J., Broer, S., Andrikopoulos, S., Muller, O.J., Rose, A.J. (2020). Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution. Nature Communications, 11:2894. DOI: 10.1038/s41467-020-16568.


39. Freire, T., Senior, A., Perks, R., Pulpitel, T., Clark, X., Brandon, A., Wahl, D., Hatchwell, L., Le Couteur, D., Cooney, G., Larance, M., Simpson, S., Solon-Biet, S.M. Sex-specific metabolic responses to 6 hours fasting during the active phase in young mice. Journal of Physiology. DOI: 10.1113/JP278806.

38. Hew, J., Parungao, R., Shi, P.H., Tsai, K., Ma, D., Nicholls, C., Li, Z., Solon-Biet, S.M.,  D’Souz, M., Le Couteur, D., Simpson, S.J., Jeschke, M.G. Maitz, P., Wang, Y. (2020). The geometric framework reveals that a moderate-protein, high carbohydrate intake is optimal for severe burn injury in mice. British Journal of Nutrition, 27:1-24.


37. Wahl, D., Gokarn, R., Solon-Biet, S.M., Cogger, V.C., LaRocca, T., Raubenheimer, D., Simpson, S.J., Le Couteur, D.G. (2019). Modelling nutrition and brain aging in rodents. The Neuroscience of Aging. Elsevier, New York, in press.

36. Ribeiro, R.,* Solon-Biet, S.M*., Pulpitel, T., Senior, A., Cogger, V., Clark, X, O’Sullivan, J., Koay, Y.C., Hirani, V., Blyth, F., et al. (2019). Of older mice and men: branched-chain amino acids and body composition. DOI: 10.3390/nu11081882 *co-first author

35. Hill, C.M., Laeger, T., Dehner, M., Albarado, D.C., Clarke, B., Wanders, D., Burke, S.J., Collier, J.J., Qualls-Creekmore, E., Solon-Biet, S.M., Simpson, S.J., Berthoud, Hans-Rudolf, Munzberg, Heike, Morrison, C.D. (2019). FGF21 signals protein status to the brain and adaptively regulates food choice and metabolism. Cell Reports, 27: 2934-2947.

34. Wahl, D., Solon-Biet, S.M., Cogger, V.C., Fontana, L., Simpson, S.J., Le Couteur, D.G., Ribeiro, R.V. Aging, lifestyle and dementia. (2019). DOI: 10.1016/j.nbd.2019.104481

33. Solon-Biet, S.M., Cogger, V.C., Pultipel, T., Wahl, D., Clark, X., Bagley, E.E., Gregoriou, G.C., Senior, A.M., Wang, QP., Brandon, A.E., Perks, R., O’Sullivan, J.O., Koay, Y.C., Bell-Anderson, K., Kebede, M., Yau, B., Atkinson, C., Svineng, G., Wali, J.A., Piper, M.D.W., Juricic, P., Partridge, L., Rose, A.J., Raubenheimer, D., Cooney, G.J., Le Couteur, D.G., Simpson, S.J. (2019) Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Nature Metabolism, DOI 10.1038/s42255-019-0059-2.


32. Senior, A.M., Solon-Biet, S.M., Cogger, V.C., Le Couteur, D.G., Nakagawa, S., Raubenheimer, D., Simpson, S.J. Dietary macronutrient content, age-specific mortality and lifespan. (2019). DOI: 10.1098/rspb.2019.0393.


31. Solon-Biet, S.M., Wahl, D., Raubenheimer, D., Cogger, V.C., Le Couteur, D.G., Simpson, S.J. The Geometric Framework: an approach for studying the impact of nutrition and healthy aging. Drug Discovery Today: Disease Models. DOI: 10.1016/j.ddmod.2019.03.002.


30. Wahl, D., Gokarn, R., Mitchell, S.J., Solon-Biet, S.M., Cogger, V.C., Simpson, S.J., Le Couteur, D.G., de Cabo, R. Central nervous system SIRT1 expression is required for cued and contextual fear conditioning memory responses in aging mice. Nutrition and Healthy Aging. DOI: 10.3233/NHA-180059.


29. Koay, Y.C., Wali, J.,A., Luk, A.W.S., Macia, L., Cogger, V.C., Pulpitel, T.J., Wahl, D., Solon-Biet, S.M., Holmes, A., Simpson, S.J., O’Sullivan, J.F. (2019). Ingestion of resistant starch by mice markedly increases microbiome-derived metabolites. DOI:10.1096/fj.201900177R.


28. Morimoto, J., Senior, A., Ruiz, K., Wali, J., Pulpitel, T., Solon-Biet, S.M., Cogger, V., Raubenheimer, D., Le Couteur, D.G., Simpson, S.J., Eberhard, J. (2019). Sucrose and starch intake contribute to alveolar bone height in a rodent model of naturally occurring periodontitis. 14, e0212796


27. Wahl, D., ., Wang, Q.P., Wali, J.A., Pulpitel, T., Clark, X., Raubenheimer, D., Senior, A.M., Sinclair, D.A., Cooney, G.J., de Cabo, R., Cogger, V.C., Simpson, S.J. Le Couteur, D.G. (2018). Comparing the effects of low protein, high carbohydrate diets and caloric restriction on brain aging in mice. , 25:2234-2243.

26. Rowe, C., Figueira, W., Raubenheimer, D., ., Machovsky-Capuska, G.E. (2018). Effects of temperature on macronutrient selection, metabolic and swimming performance of the Indo-Pacific Damselfish. , 165:178. DOI:10.1007/s00227-018-3435-7.

25. Gokarn, R., Solon-Biet, S.M., Cogger, V.C., Cooney, G.C., Wahl, D., McMahon, A.C., Mitchell, J.R., Mitchell, S.M., Hine, C., de Cabo, R., Raubenheimer, D., Simpson, S.J., Le Couteur D.G. (2018). Long-term dietary macronutrients and hepatic gene expression in aging mice. Journal of Gerontology: Biological Sciences, DOI:10.1093/gerona/gly065.

24. Solon-Biet, S.M., Wahl, D., Raubenheimer, D., Le Couteur, D.G., Simpson, S.J., Cogger, V.C. A framework for uncovering the roles of calories and macronutrients in health and aging. Conn’s Handbook on Models for Human Aging (2018). Chapter 85; Elsevier, New York. 2nd Ed.


23. Gokarn, R., Solon-Biet, S.M., Youngson, N.A., Wahl, D., Cogger, V.C., McMahon, A.C., Cooney, G.J., Ballard, J.W.O., Raubenheimer, D., Morris, M.J., Simpson, S.J., Le Couteur, D.G. (2017). The relationship between dietary macronutrients and hepatic telomere length in aging mice. Journal of Gerontology: Biological Sciences DOI:

22. Polak, M., Simmons, L. W., Benoit, J.B., Ruohonen, K., Simpson, S.J., Solon-Biet, S.M. (2017) Nutritional geometry of paternal effects on embryo mortality. Proceedings of the Royal Society B, DOI: 10.1098/rspb.2017.1492.

21. Simpson, S.J., Le Couteur, D.G., Cogger, V.C., Solon-Biet, S.M., Raubenheimer, D., George, J. (2017) Nutritional geometry of liver disease including non-alcoholic fatty liver disease. Journal of Hepatology, 68:316-325. DOI: 10.1016/j.jhep.2017.

20. Wahl, D., Coogan, S.C.P., Solon-Biet, S.M., de Cabo, R., Haran, J.B., Raubenheimer, D., Cogger, V.C., Mattson, M.P., Simpson, S.J., Le Couteur, D.G. (2017). Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia. Clinical Interventions in Aging, 12:1419-1428.

19. Simpson, S.J., Le Couteur, D.G., James, D.E., George, J., Gunton, J.E., Solon-Biet, S.M., Raubenheimer, D. (2017). The Geometric Framework for Nutrition as a tool in precision medicine. DOI: 10.3233/NHA-170027.

18. Faiman, R., Solon-Biet, S.M., Sullivan, M., Huestis, D.L., Lehmann, T. (2017). The contribution of dietary restriction to extend longevity in the malaria vector Anopheles coluzzi. Parasites & Vectors, 10:156.

17. Simpson, S.J., Le Couteur, D.G., Raubenheimer, D., Solon-Biet, S.M., Cooney, G.J., Cogger, V.C., Fontana, L. (2017). Dietary protein, aging and nutritional geometry. Ageing Research Reviews,


16. Hew, J., Solon-Biet, S.M*., McMahon, A.C., Ruohonen, K., Raubenheimer, D., Ballard, J.W.O., Le Couteur, D.G., Nicholls, C., Li, Z., Maitz, P.K.M., et al. (2016). The effects of dietary macronutrient balance on skin structure in aging male and female mice. PLoS ONE, 11:e0166175. *co-first author

15. Solon-Biet, S.M., Cogger, V.C., Pulpitel, T., Heblinski, M., Wahl, D., McMahon, A.C., Warren, A., Durrant-Whyte, J., Gokarn, R., Wali, J., et al. (2016). Defining the nutritional and metabolic context of fgf21 using the geometric framework. Cell Metabolism, 24(4):555-565.

14. Holmes, A.J., Chew, Y., Colakoglu, F., Cliff, J.B., Klaassens, E., Read, M.N., Solon-Biet, S.M., McMahon, A.C., Cogger, V.C., Ruohonen, K., et al. (2016). Diet-microbiome interactions in health are controlled by intestinal nitrogen source constraints. Cell Metabolism, 25(1):140-151.

13. Wahl, D., Cogger, V.C., Solon-Biet, S.M., Waern, R.V., Gokarn, R., Pulpitel, T., Cabo, R., Mattson, M.P., Raubenheimer, D., Simpson, S.J., Le Couteur, D.G. Nutritional strategies to optimise cognitive function in the aging brain. (2016). Ageing Research Reviews, 31:80-92.

12. Raubenheimer, D., Simpson, S.J., Le Couteur, D.G., Solon-Biet, S.M., Coogan, S.C.P. Nutritional ecology and the evolution of aging. (2016). Experimental Gerontology, 86:50-61.

11. Mohamad, M., Mitchell, S.J., Wu, L.E., White, M.Y., Cordwell, S.J., Mach, J., Solon-Biet, S.M., Boyer, D., Nines, D., Das, A., Li, S.C., Warren, A., Hilmer, S.N., Fraser, R., Sinclair, D.A., Simpson, S.J., de Cabo, R., Le Couteur, D.G., Cogger, V.C. (2016). Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance. Aging Cell. 15(4):706-15.

10. Le Couteur, D.G., Solon-Biet, S.M., Wahl, D., Cogger, V.C., Willcox, B.J., Willcox, D.C., Raubenheimer, D., Simpson, S.J. Dietary protein, ageing and the Okinawan ratio. (2016). Age and Ageing, 45(4):443-7.

9. Cogger, V.C., Mohamad, M., Solon-Biet, S.M., Senior, A., Warren, A., O’Reilly, J., Tung, B.T., Svistounov, D., McMahon, A., Fraser, R., Raubenheimer, D., Holmes, A., Simpson, S.J., Le Couteur, D.G. (2016). Dietary Macronutrients and the aging liver sinusoidal endothelial cell. American Journal of Physiology Heart and Circulatory Physiology, 310(9):H1064-70.

8. Le Couteur, D.G., Solon-Biet, S.M., Cogger, V.C., Mitchell, S.J., Senior, A., de Cabo, R., Raubenheimer, D., Simpson, S.J. (2016). The impact of low-protein high-carbohydrate diets on aging and lifespan. Cellular and Molecular Life Sciences, 73(6):1237-52.


7. Solon-Biet, S.M., Mitchell, S.J., De Cabo, R., Raubenheimer, D., Le Couteur, D.G., Simpson, S.J. (2015). Macronutrients and caloric intake in health and longevity. Journal of Endocrinology, 226:R17-R28.

6. Solon-Biet, S.M., Mitchell, S.J., Coogan, S.P.C., Cogger, V.C., Gokarn, R., McMahon, A.C., Raubenheimer, D., de Cabo, R., Simpson, S.J., Le Couteur, D.G. (2015). Dietary protein to carbohydrate ratio and caloric restriction: comparing metabolic outcomes in mice. Cell Reports, 11:1-6.

5. Solon-Biet, S.M., Walters, K.A., Simanainen, U., McMahon, A.C., Ruohonen, K., Ballard, J.W.O., Raubenheimer, D., Handelsman, D.J., Le Couteur, D.G., Simpson, S.J. (2015). Macronutrient balance, reproductive function and lifespan in aging mice.  Proceeding of the National Academy of Science, 112: 3481-3486.


4. Solon-Biet, S. M., McMahon, A. C., Ballard, J. W. O., Ruohonen, K., Wu, L. E., Cogger, V.C., Warren, A., Huang, X., pichaud, N., Melvin, R. G., Gokarn, R., Khalil, M., Turner, N., Cooney, G. J., Sinclair, D. A., Raubenheimer, D., Le Couteur, D. G., Simpson, S.J. (2014). The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice. Cell Metabolism, 19, 418-430.

3. Le Couteur, D., Tay, S., Solon-Biet, S. M., Bertolino, P., McMahon, A.C., Cogger, V., Colakoglu, F., Warren, A., Holmes, A., Pichaud, N., Horan, M., Correa, C., Melvin, R., Turner, N., Ballard, J.W., Ruohonen, K., Raubenheimer, D., Simpson, S.J. (2014). The influence of macronutrients on splanchnic and hepatic lymphocytes in aging mice. Journal of Gerontology: Biological Sciences, 196:1-9.


2. Cogger, V. C., Svistounov, D., Warren, A., Zykova, S., Melvin, R. G., Solon-Biet, S. M., O’Reilly, J. N., McMahon, A. C., Ballard, J. W. O., de Cabo, R., Le Couteur, D. G. & Lebel, M. (2013). Liver aging and pseudocapillarization in a werner syndrome mouse model. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 69(9):1076-86.

1. Huang, X., Hancock, D. P., Gosby, A. K., McMahon, A. C., Solon, S. M. C., Le Couteur, D. G., Conigrave, A. D., Raubenheimer, D. & Simpson, S. J. (2013). Effects of dietary protein to carbohydrate balance on energy intake, fat storage, and heat production in mice. Obesity, 21, 85-92.


bottom of page