“The joy of discovery is certainly the liveliest that the mind of man can ever feel”

- Claude Bernard -

Please click on the titles for a link to the article.
If you'd like a copy of a publication, please get in touch. I am happy to provide PDFs



43. Xu, X., Solon-Biet, S.M., Senior, A., Raubenheimer, D., Simpson, S.J., Fontana, L., Mueller, S. Yang, J.Y.H. (2020) LC-N2G: a local consistency approach for nutrigenomics data analysis. BMC Bioinformatics, 21:530. DOI: 10.1186/s12859-020-03861-3.


42. Le Couteur, D.G., Solon-Biet, S.M., Cogger, V.C., Ribeiro, R., de Cabo, R., Raubenheimer, D., Cooney, G.J., Simpson, S.J. (2020). Branched chain amino acids, aging and age-related health. Ageing Research Reviews, 64:101198. DOI: 10.1016/j.arr.2020.101198.


41. Rodriguez Paris, V., Solon-Biet, S.M., Senior, A.M., Edwards, M.C., Desai, R., Tedla, N., Cox, M.J., Ledger, W.L., Gilchrist, R.B., Simpson, S.J., Handelsman, D.J., Walters, K.A. (2020). Defining the impact of dietary macronutrient balance on PCOS traits. Nature Communications, 11:5262. DOI: 10.1038/s41467-020-19003-5.

40. Yap, Y.Y., Rusu, P.M., Chan, A.Y., Fam, B.C., Jungmann, A., Solon-Biet, S.M., Barlow, C.K., Creek, D.J., Huang, C., Schittenhelm, R.B., Morgan, B., Schmoll, D., Kiens, B., Piper, M.D.W., Heikenwalder, M., Simpson, S.J., Broer, S., Andrikopoulos, S., Muller, O.J., Rose, A.J. (2020). Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution. Nature Communications, 11:2894. DOI: 10.1038/s41467-020-16568.


39. Freire, T., Senior, A., Perks, R., Pulpitel, T., Clark, X., Brandon, A., Wahl, D., Hatchwell, L., Le Couteur, D., Cooney, G., Larance, M., Simpson, S., Solon-Biet, S.M. Sex-specific metabolic responses to 6 hours fasting during the active phase in young mice. Journal of Physiology. DOI: 10.1113/JP278806.

38. Hew, J., Parungao, R., Shi, P.H., Tsai, K., Ma, D., Nicholls, C., Li, Z., Solon-Biet, S.M.,  D’Souz, M., Le Couteur, D., Simpson, S.J., Jeschke, M.G. Maitz, P., Wang, Y. (2020). The geometric framework reveals that a moderate-protein, high carbohydrate intake is optimal for severe burn injury in mice. British Journal of Nutrition, 27:1-24.


37. Wahl, D., Gokarn, R., Solon-Biet, S.M., Cogger, V.C., LaRocca, T., Raubenheimer, D., Simpson, S.J., Le Couteur, D.G. (2019). Modelling nutrition and brain aging in rodents. The Neuroscience of Aging. Elsevier, New York, in press.

36. Ribeiro, R.,* Solon-Biet, S.M*., Pulpitel, T., Senior, A., Cogger, V., Clark, X, O’Sullivan, J., Koay, Y.C., Hirani, V., Blyth, F., et al. (2019). Of older mice and men: branched-chain amino acids and body composition. DOI: 10.3390/nu11081882 *co-first author

35. Hill, C.M., Laeger, T., Dehner, M., Albarado, D.C., Clarke, B., Wanders, D., Burke, S.J., Collier, J.J., Qualls-Creekmore, E., Solon-Biet, S.M., Simpson, S.J., Berthoud, Hans-Rudolf, Munzberg, Heike, Morrison, C.D. (2019). FGF21 signals protein status to the brain and adaptively regulates food choice and metabolism. Cell Reports, 27: 2934-2947.

34. Wahl, D., Solon-Biet, S.M., Cogger, V.C., Fontana, L., Simpson, S.J., Le Couteur, D.G., Ribeiro, R.V. Aging, lifestyle and dementia. (2019). DOI: 10.1016/j.nbd.2019.104481

33. Solon-Biet, S.M., Cogger, V.C., Pultipel, T., Wahl, D., Clark, X., Bagley, E.E., Gregoriou, G.C., Senior, A.M., Wang, QP., Brandon, A.E., Perks, R., O’Sullivan, J.O., Koay, Y.C., Bell-Anderson, K., Kebede, M., Yau, B., Atkinson, C., Svineng, G., Wali, J.A., Piper, M.D.W., Juricic, P., Partridge, L., Rose, A.J., Raubenheimer, D., Cooney, G.J., Le Couteur, D.G., Simpson, S.J. (2019) Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Nature Metabolism, DOI 10.1038/s42255-019-0059-2.


32. Senior, A.M., Solon-Biet, S.M., Cogger, V.C., Le Couteur, D.G., Nakagawa, S., Raubenheimer, D., Simpson, S.J. Dietary macronutrient content, age-specific mortality and lifespan. (2019). DOI: 10.1098/rspb.2019.0393.


31. Solon-Biet, S.M., Wahl, D., Raubenheimer, D., Cogger, V.C., Le Couteur, D.G., Simpson, S.J. The Geometric Framework: an approach for studying the impact of nutrition and healthy aging. Drug Discovery Today: Disease Models. DOI: 10.1016/j.ddmod.2019.03.002.


30. Wahl, D., Gokarn, R., Mitchell, S.J., Solon-Biet, S.M., Cogger, V.C., Simpson, S.J., Le Couteur, D.G., de Cabo, R. Central nervous system SIRT1 expression is required for cued and contextual fear conditioning memory responses in aging mice. Nutrition and Healthy Aging. DOI: 10.3233/NHA-180059.


29. Koay, Y.C., Wali, J.,A., Luk, A.W.S., Macia, L., Cogger, V.C., Pulpitel, T.J., Wahl, D., Solon-Biet, S.M., Holmes, A., Simpson, S.J., O’Sullivan, J.F. (2019). Ingestion of resistant starch by mice markedly increases microbiome-derived metabolites. DOI:10.1096/fj.201900177R.


28. Morimoto, J., Senior, A., Ruiz, K., Wali, J., Pulpitel, T., Solon-Biet, S.M., Cogger, V., Raubenheimer, D., Le Couteur, D.G., Simpson, S.J., Eberhard, J. (2019). Sucrose and starch intake contribute to alveolar bone height in a rodent model of naturally occurring periodontitis. 14, e0212796


27. Wahl, D., ., Wang, Q.P., Wali, J.A., Pulpitel, T., Clark, X., Raubenheimer, D., Senior, A.M., Sinclair, D.A., Cooney, G.J., de Cabo, R., Cogger, V.C., Simpson, S.J. Le Couteur, D.G. (2018). Comparing the effects of low protein, high carbohydrate diets and caloric restriction on brain aging in mice. , 25:2234-2243.

26. Rowe, C., Figueira, W., Raubenheimer, D., ., Machovsky-Capuska, G.E. (2018). Effects of temperature on macronutrient selection, metabolic and swimming performance of the Indo-Pacific Damselfish. , 165:178. DOI:10.1007/s00227-018-3435-7.

25. Gokarn, R., Solon-Biet, S.M., Cogger, V.C., Cooney, G.C., Wahl, D., McMahon, A.C., Mitchell, J.R., Mitchell, S.M., Hine, C., de Cabo, R., Raubenheimer, D., Simpson, S.J., Le Couteur D.G. (2018). Long-term dietary macronutrients and hepatic gene expression in aging mice. Journal of Gerontology: Biological Sciences, DOI:10.1093/gerona/gly065.

24. Solon-Biet, S.M., Wahl, D., Raubenheimer, D., Le Couteur, D.G., Simpson, S.J., Cogger, V.C. A framework for uncovering the roles of calories and macronutrients in health and aging. Conn’s Handbook on Models for Human Aging (2018). Chapter 85; Elsevier, New York. 2nd Ed.


23. Gokarn, R., Solon-Biet, S.M., Youngson, N.A., Wahl, D., Cogger, V.C., McMahon, A.C., Cooney, G.J., Ballard, J.W.O., Raubenheimer, D., Morris, M.J., Simpson, S.J., Le Couteur, D.G. (2017). The relationship between dietary macronutrients and hepatic telomere length in aging mice. Journal of Gerontology: Biological Sciences DOI:

22. Polak, M., Simmons, L. W., Benoit, J.B., Ruohonen, K., Simpson, S.J., Solon-Biet, S.M. (2017) Nutritional geometry of paternal effects on embryo mortality. Proceedings of the Royal Society B, DOI: 10.1098/rspb.2017.1492.

21. Simpson, S.J., Le Couteur, D.G., Cogger, V.C., Solon-Biet, S.M., Raubenheimer, D., George, J. (2017) Nutritional geometry of liver disease including non-alcoholic fatty liver disease. Journal of Hepatology, 68:316-325. DOI: 10.1016/j.jhep.2017.

20. Wahl, D., Coogan, S.C.P., Solon-Biet, S.M., de Cabo, R., Haran, J.B., Raubenheimer, D., Cogger, V.C., Mattson, M.P., Simpson, S.J., Le Couteur, D.G. (2017). Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia. Clinical Interventions in Aging, 12:1419-1428.

19. Simpson, S.J., Le Couteur, D.G., James, D.E., George, J., Gunton, J.E., Solon-Biet, S.M., Raubenheimer, D. (2017). The Geometric Framework for Nutrition as a tool in precision medicine. DOI: 10.3233/NHA-170027.

18. Faiman, R., Solon-Biet, S.M., Sullivan, M., Huestis, D.L., Lehmann, T. (2017). The contribution of dietary restriction to extend longevity in the malaria vector Anopheles coluzzi. Parasites & Vectors, 10:156.

17. Simpson, S.J., Le Couteur, D.G., Raubenheimer, D., Solon-Biet, S.M., Cooney, G.J., Cogger, V.C., Fontana, L. (2017). Dietary protein, aging and nutritional geometry. Ageing Research Reviews,


16. Hew, J., Solon-Biet, S.M*., McMahon, A.C., Ruohonen, K., Raubenheimer, D., Ballard, J.W.O., Le Couteur, D.G., Nicholls, C., Li, Z., Maitz, P.K.M., et al. (2016). The effects of dietary macronutrient balance on skin structure in aging male and female mice. PLoS ONE, 11:e0166175. *co-first author

15. Solon-Biet, S.M., Cogger, V.C., Pulpitel, T., Heblinski, M., Wahl, D., McMahon, A.C., Warren, A., Durrant-Whyte, J., Gokarn, R., Wali, J., et al. (2016). Defining the nutritional and metabolic context of fgf21 using the geometric framework. Cell Metabolism, 24(4):555-565.

14. Holmes, A.J., Chew, Y., Colakoglu, F., Cliff, J.B., Klaassens, E., Read, M.N., Solon-Biet, S.M., McMahon, A.C., Cogger, V.C., Ruohonen, K., et al. (2016). Diet-microbiome interactions in health are controlled by intestinal nitrogen source constraints. Cell Metabolism, 25(1):140-151.

13. Wahl, D., Cogger, V.C., Solon-Biet, S.M., Waern, R.V., Gokarn, R., Pulpitel, T., Cabo, R., Mattson, M.P., Raubenheimer, D., Simpson, S.J., Le Couteur, D.G. Nutritional strategies to optimise cognitive function in the aging brain. (2016). Ageing Research Reviews, 31:80-92.

12. Raubenheimer, D., Simpson, S.J., Le Couteur, D.G., Solon-Biet, S.M., Coogan, S.C.P. Nutritional ecology and the evolution of aging. (2016). Experimental Gerontology, 86:50-61.

11. Mohamad, M., Mitchell, S.J., Wu, L.E., White, M.Y., Cordwell, S.J., Mach, J., Solon-Biet, S.M., Boyer, D., Nines, D., Das, A., Li, S.C., Warren, A., Hilmer, S.N., Fraser, R., Sinclair, D.A., Simpson, S.J., de Cabo, R., Le Couteur, D.G., Cogger, V.C. (2016). Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance. Aging Cell. 15(4):706-15.

10. Le Couteur, D.G., Solon-Biet, S.M., Wahl, D., Cogger, V.C., Willcox, B.J., Willcox, D.C., Raubenheimer, D., Simpson, S.J. Dietary protein, ageing and the Okinawan ratio. (2016). Age and Ageing, 45(4):443-7.

9. Cogger, V.C., Mohamad, M., Solon-Biet, S.M., Senior, A., Warren, A., O’Reilly, J., Tung, B.T., Svistounov, D., McMahon, A., Fraser, R., Raubenheimer, D., Holmes, A., Simpson, S.J., Le Couteur, D.G. (2016). Dietary Macronutrients and the aging liver sinusoidal endothelial cell. American Journal of Physiology Heart and Circulatory Physiology, 310(9):H1064-70.

8. Le Couteur, D.G., Solon-Biet, S.M., Cogger, V.C., Mitchell, S.J., Senior, A., de Cabo, R., Raubenheimer, D., Simpson, S.J. (2016). The impact of low-protein high-carbohydrate diets on aging and lifespan. Cellular and Molecular Life Sciences, 73(6):1237-52.


7. Solon-Biet, S.M., Mitchell, S.J., De Cabo, R., Raubenheimer, D., Le Couteur, D.G., Simpson, S.J. (2015). Macronutrients and caloric intake in health and longevity. Journal of Endocrinology, 226:R17-R28.

6. Solon-Biet, S.M., Mitchell, S.J., Coogan, S.P.C., Cogger, V.C., Gokarn, R., McMahon, A.C., Raubenheimer, D., de Cabo, R., Simpson, S.J., Le Couteur, D.G. (2015). Dietary protein to carbohydrate ratio and caloric restriction: comparing metabolic outcomes in mice. Cell Reports, 11:1-6.

5. Solon-Biet, S.M., Walters, K.A., Simanainen, U., McMahon, A.C., Ruohonen, K., Ballard, J.W.O., Raubenheimer, D., Handelsman, D.J., Le Couteur, D.G., Simpson, S.J. (2015). Macronutrient balance, reproductive function and lifespan in aging mice.  Proceeding of the National Academy of Science, 112: 3481-3486.


4. Solon-Biet, S. M., McMahon, A. C., Ballard, J. W. O., Ruohonen, K., Wu, L. E., Cogger, V.C., Warren, A., Huang, X., pichaud, N., Melvin, R. G., Gokarn, R., Khalil, M., Turner, N., Cooney, G. J., Sinclair, D. A., Raubenheimer, D., Le Couteur, D. G., Simpson, S.J. (2014). The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice. Cell Metabolism, 19, 418-430.

3. Le Couteur, D., Tay, S., Solon-Biet, S. M., Bertolino, P., McMahon, A.C., Cogger, V., Colakoglu, F., Warren, A., Holmes, A., Pichaud, N., Horan, M., Correa, C., Melvin, R., Turner, N., Ballard, J.W., Ruohonen, K., Raubenheimer, D., Simpson, S.J. (2014). The influence of macronutrients on splanchnic and hepatic lymphocytes in aging mice. Journal of Gerontology: Biological Sciences, 196:1-9.


2. Cogger, V. C., Svistounov, D., Warren, A., Zykova, S., Melvin, R. G., Solon-Biet, S. M., O’Reilly, J. N., McMahon, A. C., Ballard, J. W. O., de Cabo, R., Le Couteur, D. G. & Lebel, M. (2013). Liver aging and pseudocapillarization in a werner syndrome mouse model. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 69(9):1076-86.

1. Huang, X., Hancock, D. P., Gosby, A. K., McMahon, A. C., Solon, S. M. C., Le Couteur, D. G., Conigrave, A. D., Raubenheimer, D. & Simpson, S. J. (2013). Effects of dietary protein to carbohydrate balance on energy intake, fat storage, and heat production in mice. Obesity, 21, 85-92.


Awards & Funding


Robinson Fellowship (declined), University of Sydney

Australia and New Zealand Obesity Society (ANZOS) Young Investigator Award

University of Sydney Robinson Fellowship

L'Oreal-UNESCO For Women in Science Fellowship


Vice Chancellor's Awards for Excellence (Outstanding Early Career Research)

Poster Pitch Prize, Nature Conference on Ageing, Health and Rejuvination


NSW Young Tall Poppy Science Award

University of Sydney representative for the Australian Academy of Sciences Early to Mid-Career Researchers Forum.

Sydney Research Accelerator (SOAR) Fellowship. Age-defying nutrition.

Charles Perkins Centre Early to Mid-Career Researcher (EMCR) seed funding. Put down the protein shake: what BCAAs may be doing to your long-term health.

Australian Research Council Discovery Project. A life-course approach to the nutrition-lifepsan-reproduction nexus.

Harvard University Mobility Scheme (Boston, MA USA). Hydrogen sulfide in ageing.


Ian Potter Foundation travel award (Les Diablerets, Switzerland). Ageing and latelife health: calories or macronutrients?

Top 5 Under 40 program (Top 10 in Australia). Nutritional modelling of ageing.



Best Oral Presentation (Rank Prize Funds on Dietary Restriction and Ageing, United Kingdom). Defining the nutritional and metabolic context of FGF21 using the Geometric Framework.


Top 10 Research Articles and Reviews (Journal of Endocrinology). Macronutrients and caloric intake in health and longevity.


Paper published in Cell Metabolism in the top 5% of all research outputs scored by Altmetric. The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice.


Best Oral Presentation (Australian Society for Medical Research, Australia). The role of macronutrient balance on appetite, cardiometabolic health and ageing in a mouse model.


Best Oral Presentation (11th National Conference of Emerging Researchers in Ageing, Australia). Macronutrient balance, metabolic health and ageing in mice.